Kaname & Ruka

Kaname Kuran and Ruka Souen Ruka Souen, a noble vampire, is in love with Kaname Kuran, a pureblood, maybe since she first met him or she started having feelings toward the pureblood when she entered Cross Academy. However Kaname never met her feelings and barely makes note of them. Ruka however does not lose her hopes and has tried to make him drink her blood on past occasions.

It is important to say that Ruka once offered her blood to Kaname when Yuuki was sleeping as a child. She knew that Kaname was protecting Yuuki for a reason and, if he bit her, he would regret it later. They then left the room and Kaname bit Ruka, like she had wanted. Kaname did it to help show Yuuki what he truly was, hoping it would keep her away from him for awhile. Ruka knew that there would be repricusions, back then, she didn't really care, she was doing what she thought was right.

Ruka's one of the many collateral-effects Kaname made following his plans still, she somewhat obliges and stays by the pureblood's side, knowing she has little to no chance of actually getting something more than a friendship. Ruka seems to have given up on trying to get Kaname to love her and will accept that he won't. This fact makes their relationship one of the saddest in Vampire Knight, although it is also satisfying to not see a character like her degenerate and wishing bad to fall on the pureblood.